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Value of Sonographic Bidirectional Arterial Flow Combined With Elastography for Diagnosis of Breast Imaging Reporting and Data System Category 4 Breast Masses
Author(s) -
Liu Da,
Huang Ying,
Tian Dan,
Yin Jing,
Deng Li-jun
Publication year - 2015
Publication title -
journal of ultrasound in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 91
eISSN - 1550-9613
pISSN - 0278-4297
DOI - 10.7863/ultra.35.5.759
Subject(s) - medicine , elastography , breast imaging , receiver operating characteristic , confidence interval , radiology , bi rads , ultrasound , area under the curve , cutoff , positive predicative value , nuclear medicine , predictive value , breast cancer , mammography , physics , cancer , quantum mechanics
Objectives The purpose of this study was to evaluate the role of bidirectional arterial flow combined with ultrasound elastography for differentiation of American College of Radiology Breast Imaging Reporting and Data System (BI‐RADS) category 4 masses. Methods A total of 116 BI‐RADS category 4 breast masses were evaluated with color Doppler sonography, spectral analysis, and elastography. The sensitivity, specificity, accuracy, positive and negative predictive values, and receiver operator characteristic curve were used to estimate the diagnostic performance for each modality and the combination method. Results The combination method had the best sensitivity (81.1%) but less specificity (94.9%) and the best accuracy (90.5%). The discriminating power of the combined method (area under the curve [AUC], 0.880; 95% confidence interval [CI], 80.0%–96.0%) was significantly higher than that of bidirectional arterial flow (AUC, 0.818; 95% CI, 72.0%–91.6%; P < .01) and elastography (AUC, 0.765; 95% CI, 65.9%–87.0%; P < .01). Conclusions Bidirectional arterial flow evaluation, when combined with elastography, could potentially improve diagnostic accuracy for BI‐RADS category 4 breast masses.