Chorionic Bump in Pregnant Patients and Associated Live Birth Rate

Objectives A chorionic bump on first‐trimester sonography has been considered a risk factor for nonviability in pregnant patients with this rare finding, although the strength of this association has recently been questioned. We performed a systematic review and meta‐analysis to summarize the association between a chorionic bump and nonviability. Methods A comprehensive literature search was performed. We included all studies except case reports. A meta‐analysis was performed using a random‐effects model. Results After screening 5 studies, 2 studies with a total of 67 patients met inclusion criteria. These were combined with a study (n = 52) from our institution. Overall, the live birth rate was 62% (74 of 119). Fifty‐one chorionic bump pregnancies were otherwise normal (ie, pregnancies in which a gestational sac, a yolk sac, and an embryo with a heartbeat was seen at some point), and in this subset, the live birth rate was 83% (42 of 51). There was no significant relationship found between vaginal bleeding and live birth ( P = .857); there was no significant difference in bump volume between live birth and no live birth ( P = .198); and for the subset analysis of pooled odds ratios for the relationship between live birth and history of infertility, there was no significant relationship found ( P = .186). Conclusions A chorionic bump remains a risk factor for nonviability in pregnancy; however, if the pregnancy is otherwise normal, then most result in live birth.