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Effects of High‐Intensity Focused Ultrasound for Treatment of Abdominal Lymph Node Metastasis From Gastric Cancer
Author(s) -
Zhang Meiling,
Liu Lingxiang,
Wang Jian,
Lu Kaihua,
Shu Yongqian,
Wang Rongsheng,
Liu Ping
Publication year - 2015
Publication title -
journal of ultrasound in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 91
eISSN - 1550-9613
pISSN - 0278-4297
DOI - 10.7863/ultra.34.3.435
Subject(s) - medicine , chemotherapy , high intensity focused ultrasound , lymph node , metastasis , cancer , lymph , lymph node metastasis , radiology , oncology , ultrasound , pathology
Objectives This retrospective study aimed to compare the efficacy and safety of combination treatment with high‐intensity focused ultrasound (HIFU) and chemotherapy to those of chemotherapy alone for treatment of the abdominal lymph node metastasis from gastric cancer. Methods A total of 185 patients with gastric cancer and abdominal lymph node metastasis were enrolled and divided into 2 groups: group A received chemotherapy alone (n = 102); group B received HIFU combined with chemotherapy (n = 83). The clinical efficacy and safety of the groups were then analyzed. Results The overall response rates of groups A and B were 34.3% and 47.0%, respectively ( P = .046). The pain relief rates in groups A and B were 51.6% and 75.0% ( P = .039). At the data cutoff, the median survival times of groups A and B were 8.6 and 11.9 months ( P < .05). The adverse reactions in the groups did not show significant differences ( P > .05). Among the patients treated with HIFU and chemotherapy, those with small abdominal lymph nodes (diameter <3 cm) had a better prognosis than those with large nodes (diameter ≥3 cm). Conclusions In patients with gastric cancer and abdominal lymph node metastasis, the combination of HIFU and chemotherapy can provide clinical benefits. High‐intensity focused ultrasound could effectively facilitate treatment of abdominal lymph node metastasis from gastric cancer.