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Collaborative Study of 4‐Dimensional Fetal Echocardiography in the First Trimester of Pregnancy
Author(s) -
Espinoza Jimmy,
Lee Wesley,
Viñals Fernando,
Martinez Josep Maria,
Bennasar Mar,
Rizzo Giuseppe,
Belfort Michael
Publication year - 2014
Publication title -
journal of ultrasound in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 91
eISSN - 1550-9613
pISSN - 0278-4297
DOI - 10.7863/ultra.33.6.1079
Subject(s) - medicine , fetal echocardiography , pregnancy , fetus , cardiology , first trimester , fetal heart , prenatal diagnosis , heart defect , obstetrics , heart disease , genetics , biology
Objectives Accumulating evidence supports a role for 2‐dimensional fetal echocardiography in the first trimester of pregnancy for the identification of congenital heart defects. Our objective was to investigate the role of 4‐dimensional (4D) sonography in the identification of congenital heart defects between 11 and 15 weeks of pregnancy. Methods This study included 4 centers with expertise in first‐trimester 4D fetal echocardiography. Fetuses with and without confirmed heart defects were evaluated between 11 and 15 weeks and their volume data sets were uploaded onto a centralized file transfer protocol server. Results Forty‐eight volume data sets from fetuses with normal (n = 17) and abnormal (n = 16) hearts were evaluated. Overall, the median (range) accuracy, sensitivity, and specificity, as well as the positive and negative likelihood ratios, for the identification of fetuses with congenital heart defects were 79% (77%–83%), 90% (70%–96%), 59% (58%–93%), 2.35 (2.05–9.80), and 0.18 (0.08–0.32), respectively. Conclusions (1) Four‐dimensional fetal echocardiography can be performed in the first and early second trimesters of pregnancy; and (2) 4D volume data sets obtained from fetuses between 11 and 15 weeks can be remotely acquired and accurately interpreted by different centers.