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Evaluation of the Impact of Passive Smoke on Arterial Elasticity via Echo‐Tracking Technology in a Rabbit Model
Author(s) -
Qiang Yong,
Ruijun Guo,
Zhen Chen,
Zhian Li,
Changyan Lin,
Xiaohui Yang,
Shu Liu,
Jie Lin,
Yuanfeng Meng,
Ruobing Zhang,
Yan Cao,
Qiao Ma,
Shuang Zhang,
Zhu Yuping
Publication year - 2014
Publication title -
journal of ultrasound in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 91
eISSN - 1550-9613
pISSN - 0278-4297
DOI - 10.7863/ultra.33.11.1949
Subject(s) - medicine , pulse wave velocity , arterial stiffness , elasticity (physics) , abdominal aorta , aorta , in vivo , passive smoking , biomedical engineering , cardiology , radiology , nuclear medicine , pathology , blood pressure , materials science , microbiology and biotechnology , composite material , biology
Objectives The purpose of this study was to evaluate the elasticity of the abdominal aorta in passively smoking rabbits using echo‐tracking technology and pathologic examination. Methods Fifty‐four male New Zealand White rabbits were randomly divided into a passive smoking group and a normal control group. The elasticity indicators for the abdominal aorta of the rabbits were measured by means of echo tracking, which was performed before and 1, 2, and 3 months after passive smoking. Measured indicators included the pressure‐strain elastic modulus, stiffness, arterial compliance, augmentation index, and pulse wave velocity. After the completion of the in vivo measurements, rabbits were euthanized randomly, and the corresponding arterial sites were resected for pathologic examination and in vitro measurement of vascular elasticity. Results The echo‐tracking technology used in our research proved that the elastic modulus, stiffness, and pulse wave velocity gradually increased with time by passive smoking, whereas arterial compliance decreased by passive smoking. Pathologic examination and in vitro measurements were performed and further confirmed the observed in vivo results. Conclusions Passive smoking can injure arteries and reduce arterial elasticity. Echo‐tracking technology is an accurate, noninvasive, and reliable method for analysis of the impact of passive smoking on arterial elasticity and detection arterial injury, which also can provide a new instructional basis for prevention and treatment of several arterial diseases.