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Transabdominal High‐Intensity Focused Ultrasound Therapy of the Prostate and Determination of the Protective Effect of Rectal Cooling
Author(s) -
Yoo Dong Hyun,
Cho Jeong Yeon,
Kwak Cheol,
Lee Jae Young,
Moon Kyung Chul,
Kim Seung Hyup
Publication year - 2013
Publication title -
journal of ultrasound in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 91
eISSN - 1550-9613
pISSN - 0278-4297
DOI - 10.7863/ultra.32.8.1419
Subject(s) - medicine , prostate , rectum , magnetic resonance imaging , high intensity focused ultrasound , ultrasound , transabdominal ultrasound , rectal temperature , rectal examination , rectal administration , urology , radiology , nuclear medicine , surgery , cancer
Objectives The purpose of this study was to report our initial experience with transabdominal high‐intensity focused ultrasound (HIFU) therapy of the canine prostate and to determine the protective effect of rectal cooling during HIFU therapy. Methods Fifteen male dogs underwent transabdominal HIFU therapy of the prostate. Transabdominal HIFU was performed on 9 dogs without using a rectal cooling device, and the remaining 6 dogs underwent transabdominal HIFU with introduction of the rectal cooling device. Magnetic resonance imaging (MRI) was performed before, immediately after, and 1 week after the HIFU procedure. Rectal changes on MRI were classified into 4 grades (grades 0–3), and a comparison of the rectal change grades on MRI between the two groups was performed with the Mann‐Whitney U test. Results The procedure failed for the first dog because of inadequate skin preparation. Of the remaining 14 dogs (8 without rectal cooling and 6 with rectal cooling), 4 showed focal signal changes in the prostate. The average rectal change grades on immediate postprocedural MRI were 2.63 for the non–rectal cooling group and 1.17 for the rectal cooling group ( P = .0216). On 1‐week follow‐up MRI, the average grades were 1.20 for the non–rectal cooling group and 0.33 for the rectal cooling group ( P = .1956). Conclusions Transabdominal HIFU of the canine prostate was technically feasible, but the effect was limited because of anatomic and physiologic factors of the canine prostate. The rectal cooling device seems to have a protective effect on the rectum during the transabdominal HIFU procedure.