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Diagnostic Efficacy of Contrast‐Enhanced Sonography by Combined Qualitative and Quantitative Analysis in Breast Lesions
Author(s) -
Wang Lin,
Du Jing,
Li Feng-Hua,
Fang Hua,
Hua Jia,
Wan Cai-Feng
Publication year - 2013
Publication title -
journal of ultrasound in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 91
eISSN - 1550-9613
pISSN - 0278-4297
DOI - 10.7863/ultra.32.10.1805
Subject(s) - medicine , concordance , radiology , magnetic resonance imaging , contrast (vision) , lesion , meglumine , nuclear medicine , pathology , artificial intelligence , computer science
Objectives The purpose of this study was to evaluate the diagnostic efficacy of contrast‐enhanced sonography for differentiation of breast lesions by combined qualitative and quantitative analyses in comparison to magnetic resonance imaging (MRI). Methods Fifty‐six patients with American College of Radiology Breast Imaging Reporting and Data System category 3 to 5 breast lesions on conventional sonography were evaluated by contrast‐enhanced sonography and MRI. A comparative analysis of diagnostic results between contrast‐enhanced sonography and MRI was conducted in light of the pathologic findings. Results Pathologic analysis showed 26 benign and 30 malignant lesions. The predominant enhancement patterns of the benign lesions on contrast‐enhanced sonography were homogeneous, centrifugal, and isoenhancement or hypoenhancement, whereas the patterns of the malignant lesions were mainly heterogeneous, centripetal, and hyperenhancement. The detection rates for perfusion defects and peripheral radial vessels in the malignant group were much higher than those in the benign group ( P < .05). As to quantitative analysis, statistically significant differences were found in peak and time‐to‐peak values between the groups ( P < .05). With pathologic findings as the reference standard, the sensitivity, specificity, and accuracy of contrast‐enhanced sonography and MRI were 90.0%, 92.3%, 91.1% and 96.7%, 88.5%, and 92.9%, respectively. The two methods had a concordant rate of 87.5% (49 of 56), and the concordance test gave a value of κ = 0.75, indicating that there was high concordance in breast lesion assessment between the two diagnostic modalities. Conclusions Contrast‐enhanced sonography provided typical enhancement patterns and valuable quantitative parameters, which showed good agreement with MRI in diagnostic efficacy and may potentially improve characterization of breast lesions.