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Carotid Intima‐Media Thickness in Patients With Carpal Tunnel Syndrome
Author(s) -
Park Joong Hyun,
Kim Shi Nae,
Han Seung Min,
Cheon Kyeong Yeol,
Han Sang Won,
Kim Jeong Yeon,
Baik Jong Sam,
Park Jae Hyeon
Publication year - 2013
Publication title -
journal of ultrasound in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 91
eISSN - 1550-9613
pISSN - 0278-4297
DOI - 10.7863/ultra.32.10.1753
Subject(s) - medicine , carpal tunnel syndrome , intima media thickness , body mass index , blood pressure , outpatient clinic , neurology , carpal tunnel , surrogate endpoint , cardiology , surgery , carotid arteries , psychiatry
Objectives We measured the carotid intima‐media thickness, a surrogate marker of early atherosclerosis, in patients with carpal tunnel syndrome compared to a control group to evaluate the risk of atherosclerotic disease. Methods Between January 2011 and December 2011, female patients presenting to the outpatient neurology clinic for pain and paresthesia in the hands were screened for study enrollment. Patients 30 years or older were eligible for the study if they did not have a history of stroke or cardiovascular disease. Results During the study period, 111 patients (58 in the carpal tunnel syndrome group and 53 in the control group) were enrolled, with a mean age of 56 years (range, 32–79 years). There were no significant differences in baseline characteristics except maximum carotid intima‐media thickness and body mass index. The maximum intima‐media thickness was greater in the carpal tunnel syndrome group (mean ± SD, 1.05 ± 0.17 mm) than the control group (0.85 ± 0.22 mm; P < .0001). The body mass index was greater among the controls ( P = .012). Simple linear regression analysis revealed that age ( P < .0001), carpal tunnel syndrome ( P < .0001), hypertension ( P = .022), and systolic blood pressure ( P = .034) were statistically significantly associated with increased intima‐media thickness. Multiple linear regression analysis revealed that hypertension ( P = .033), systolic blood pressure ( P = .022), age ( P < .0001), and carpal tunnel syndrome ( P < .0001) were significantly associated with increased intima‐media thickness, with carpal tunnel syndrome being the most influential factor (β= 0.489). Conclusions The maximum carotid intima‐media thickness was significantly increased in patients with carpal tunnel syndrome compared to controls. Chronic inflammation beyond the traditional cardiovascular risk factors might be related to increased carotid intima‐media thickness in patients with carpal tunnel syndrome.