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Ultrasound‐Guided Diffuse Optical Tomography for Differentiation of Benign and Malignant Breast Lesions: A Meta‐analysis
Author(s) -
Wu Tao,
Feng JinChun,
Tuerhong Shabier,
Wang Bin,
Yang Liang,
Zhao Qian,
Dilixiati Jinsihan,
Xu WenTing,
Zhu LiPing
Publication year - 2017
Publication title -
journal of ultrasound in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 91
eISSN - 1550-9613
pISSN - 0278-4297
DOI - 10.7863/ultra.16.03063
Subject(s) - medicine , receiver operating characteristic , confidence interval , meta analysis , ultrasound , diagnostic odds ratio , cochrane library , radiology , publication bias , odds ratio , diffuse optical imaging , nuclear medicine , area under the curve , tomography , pathology
Objectives The purpose of this study was to assess the diagnostic performance of ultrasound‐guided diffuse optical tomography for differentiation of benign and malignant breast lesions. Methods The Cochrane Library, PubMed, and Embase databases were searched from inception to February 14, 2016. Sensitivity, specificity, and other information were extracted from the included studies. Sensitivity and specificity were pooled by a bivariate mixed‐effects binary regression model. A summary receiver operating characteristic curve was constructed. Heterogeneity and publication bias were explored by Higgins and Deeks tests, respectively. Results Seven studies including 768 women with 886 lesions were analyzed. The summary sensitivity, specificity, and diagnostic odds ratio were 95% (95% confidence interval [CI], 85%–98%), 77% (95% CI, 66%–85%), and 57 (95% CI, 12–267), respectively. The area under the summary receiver operating characteristic curve was 91% (95% CI, 89%–94%). No significant heterogeneity or publication bias existed. Conclusions Ultrasound‐guided diffuse optical tomography is useful for differentiating breast lesions. Especially, its sensitivity is excellent.