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Correlation Between Flow‐Mediated Dilatation of the Brachial Artery and Serum Endothelial Biomarkers in the Evaluation of Acute Endothelial Injury After Cardiopulmonary Bypass
Author(s) -
Wang WeiJian,
Zhou JiaHao,
He GuoLiang,
Wu QiaoLin,
Gao Wei,
Sun JieHao,
Zhang PengBo
Publication year - 2017
Publication title -
journal of ultrasound in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 91
eISSN - 1550-9613
pISSN - 0278-4297
DOI - 10.7863/ultra.16.02071
Subject(s) - medicine , brachial artery , cardiopulmonary bypass , perioperative , von willebrand factor , cardiology , endothelial dysfunction , endothelium , anesthesia , blood pressure , platelet
Objectives The purpose of this study was to investigate the correlation between flow‐mediated dilatation of the brachial artery and serum endothelial biomarkers and to discuss the feasibility of sonographic evaluation of acute endothelial injury during cardiopulmonary bypass (CPB) surgery. Methods Sonography was applied to determine the percentage of change in the brachial artery size during flow‐mediated dilatation. Meanwhile, the plasma concentrations of endothelial‐derived biomarkers, such as endothelin 1, nitric oxide, and von Willebrand factor, were measured to monitor the changes in endothelial function. We analyzed the correlation between flow‐mediated dilatation and biomarkers during the perioperative period of CPB in 27 patients. Results All of the biomarkers changed dramatically, especially during the CPB period. There was a negative correlation between flow‐mediated dilatation and von Willebrand factor ( P = .001; R = −0.31). Conclusions A CPB event has a substantial impact on endothelial function, and sonographic assessment of the percentage of change in the brachial artery size during flow‐mediated dilatation allows early detection of acute endothelial function injury in cardiac surgery.