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Quantitative Ultrasound Measurement at the Hand Phalanges Does Not Reveal Skeletal Disturbances in Children With Bronchial Asthma: A Longitudinal Observation
Author(s) -
Adamczyk Piotr,
Pluskiewicz Wojciech,
Halaba Ze,
Nowakowski Marek,
Madaj Anna,
Drozdzowska Bogna
Publication year - 2017
Publication title -
journal of ultrasound in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 91
eISSN - 1550-9613
pISSN - 0278-4297
DOI - 10.7863/ultra.16.01017
Subject(s) - medicine , phalanx , asthma , ultrasound , longitudinal study , bone age , surgery , pathology , radiology
Objectives To assess the skeletal status in asthmatic children treated with inhaled corticosteroids in a longitudinal observation by quantitative ultrasound (US) measurement at the hand phalanges. Methods Thirty‐four children were studied prospectively. Quantitative US measurements were performed at baseline and after a mean ± SD of 2.35 ± 0.20 years. The obtained results were compared to age‐, sex‐, and body size‐matched control participants selected from a database of previously examined healthy children. Individual changes in the amplitude‐dependent speed of sound (Ad‐SoS) during the follow‐up period were also analyzed. Results The mean age of the asthmatic children was 10.6 ± 2.5 years. The mean Ad‐SoS in the asthmatic children at baseline was 1940.5 ± 49.6 m/s, and the mean Z score was −0.26 ± 0.80. Corresponding values at the follow‐up examination were 1976.2 ± 63.6 m/s and −0.18 ± 1.16. The results did not differ significantly in comparison to the healthy controls. The analysis of individual changes in Ad‐SoS revealed that 18 participants had a significant increase in this parameter (ie, exceeding the least significant change threshold), and 16 did not have a significant change in their values. No one had a significant decrease in Ad‐SoS. Conclusions Quantitative US at the hand phalanges applied as a diagnostic tool revealed no essential differences in the pattern of skeletal development between asthmatic children treated with inhaled glucocorticosteroids and healthy controls.