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Diagnostic Efficacy and Safety of Endobronchial Ultrasound‐Guided Transbronchial Needle Aspiration in Intrathoracic Tuberculosis
Author(s) -
Ye Wu,
Zhang Ruifeng,
Xu Xiaoling,
Liu Yanru,
Ying Kejing
Publication year - 2015
Publication title -
journal of ultrasound in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 91
eISSN - 1550-9613
pISSN - 0278-4297
DOI - 10.7863/ultra.15.14.06017
Subject(s) - medicine , diagnostic odds ratio , confidence interval , receiver operating characteristic , odds ratio , likelihood ratios in diagnostic testing , radiology , endobronchial ultrasound , tuberculosis , area under the curve , meta analysis , cochrane library , bronchoscopy , pathology
Objectives Endobronchial ultrasound‐guided transbronchial needle aspiration (EBUS‐TBNA) is a minimally invasive technique. A meta‐analysis was performed to assess the efficacy and safety of EBUS‐TBNA in intrathoracic tuberculosis (TB). Methods We searched PubMed, the Cochrane Library, and the Web of Science for suitable studies. The pooled sensitivity, specificity, likelihood ratios (LRs), and diagnostic odds ratio were calculated. A summary receiver operating characteristic (ROC) curve was constructed to calculate the area under the summary ROC curve and Q point value ( Q* ). Results A total of 8 studies with 809 patients were included. The pooled sensitivity and specificity of EBUS‐TBNA for diagnosis of intrathoracic TB were 0.80 (95% confidence interval [CI] 0.74–0.85) and 1.00 (95% CI, 0.99–1.00), respectively. The positive LR was 38.25 (95% CI, 13.59–107.65); the negative LR was 0.24 (95% CI, 0.17–0.33); and the diagnostic odds ratio was 186.35 (95% CI, 63.57–546.28). The area under the summary ROC curve was 0.935, and the Q *was 0.871. The pooled sensitivity of EBUS‐TBNA for diagnosis of intrathoracic tuberculous lymphadenopathy was 0.87 (95% CI, 0.80–0.95). Only 1 serious complication was reported. Conclusions Endobronchial US‐guided TBNA is an effective and safe diagnostic tool for intrathoracic TB, especially intrathoracic tuberculous lymphadenopathy.