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Neonatal Outcomes in Fetuses With a Persistent Intrahepatic Right Umbilical Vein
Author(s) -
Canavan Timothy P.,
Hill Lyndon M.
Publication year - 2016
Publication title -
journal of ultrasound in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 91
eISSN - 1550-9613
pISSN - 0278-4297
DOI - 10.7863/ultra.15.10015
Subject(s) - medicine , umbilical vein , fetus , aneuploidy , obstetrics , pregnancy , vein , biochemistry , chemistry , biology , gene , in vitro , chromosome , genetics
Objectives A fetal persistent intrahepatic right umbilical vein has been linked to anomalies and genetic disorders but can be a normal variant. We conducted a retrospective review to determine other sonographic findings that can stratify fetuses for further evaluation. Methods A total of 313 fetuses had a persistent intrahepatic right umbilical vein identified on 17‐ to 24‐week sonography. The outcome was any major congenital anomaly or an adverse neonatal outcome, which was defined as aneuploidy, fetal demise, or neonatal death. Results A total of 217 patients (69.3%) had a normal neonatal outcome. Sixty‐nine patients (22.0%) were lost to follow‐up. Five fetuses (2.1%) had aneuploidy; 4 of the 5 had additional sonographic findings, and 1 had an isolated persistent intrahepatic right umbilical vein. Twenty‐four fetuses had a major anomaly in association with the persistent right umbilical vein; 26 additional fetuses had soft sonographic markers associated with karyotypic abnormalities but were chromosomally normal. Of those with adverse neonatal outcomes, 12 had a congenital heart defect (57%). An additional sonographic finding with a persistent intrahepatic right umbilical vein was predictive of a congenital anomaly or an adverse neonatal outcome ( P < .001), with a positive predictive value of 44.0% (95% confidence interval, 30.0%–58.7%). An isolated persistent intrahepatic right umbilical vein had a 0.4% risk for a congenital anomaly or an adverse neonatal outcome. Conclusions A persistent intrahepatic right umbilical vein should prompt an extended anatomic survey and a fetal cardiac evaluation. If the survey and cardiac anatomy are reassuring, no further follow‐up is needed. If additional findings are identified, genetic counseling and invasive testing should be considered.