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Growth Patterns of Fetal Lung Volumes in Healthy Fetuses and Fetuses With Isolated Left‐Sided Congenital Diaphragmatic Hernia
Author(s) -
Ruano Rodrigo,
Britto Ingrid Schwach Werneck,
Sananes Nicolas,
Lee Wesley,
Sangi-Haghpeykar Haleh,
Deter Russell L.
Publication year - 2016
Publication title -
journal of ultrasound in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 91
eISSN - 1550-9613
pISSN - 0278-4297
DOI - 10.7863/ultra.15.08005
Subject(s) - medicine , congenital diaphragmatic hernia , fetus , lung , lung volumes , diaphragmatic hernia , cardiology , obstetrics , hernia , pregnancy , surgery , genetics , biology
Objectives To evaluate fetal lung growth using 3‐dimensional sonography in healthy fetuses and those with congenital diaphragmatic hernia (CDH). Methods Right and total lung volumes were serially evaluated by 3‐dimensional sonography in 66 healthy fetuses and 52 fetuses with left‐sided CDH between 20 and 37 weeks' menstrual age. Functions fitted to these parameters were compared for 2 groups: (1) healthy versus those with CDH; and (2) fetuses with CHD who survived versus those who died. Results Fetal right and total lung volumes as well as fetal observed‐to‐expected right and total lung volume ratios were significantly lower in fetuses with CDH than healthy fetuses ( P < .001) and in those fetuses with CDH who died ( P < .001). The observed‐to‐expected right and total lung volume ratios did not vary with menstrual age in healthy fetuses or in those with CDH (independent of outcome). Conclusions Lung volume rates were lower in fetuses with left‐sided CDH compared to healthy fetuses, as well as in fetuses with CDH who died compared to those who survived. The observed‐to‐expected right and total lung volume ratios were relatively constant throughout menstrual age in fetuses with left‐sided CDH, suggesting that the origin of their lung growth abnormalities occurred before 20 weeks and did not progress. The observed‐to‐expected ratios may be useful in predicting the outcome in fetuses with CDH independent of menstrual age.