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Diagnostic Accuracy of SuperSonic Shear Imaging for Staging of Liver Fibrosis
Author(s) -
Feng Jin-Chun,
Li Jun,
Wu Xiang-Wei,
Peng Xin-Yu
Publication year - 2016
Publication title -
journal of ultrasound in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 91
eISSN - 1550-9613
pISSN - 0278-4297
DOI - 10.7863/ultra.15.03032
Subject(s) - medicine , confidence interval , receiver operating characteristic , publication bias , meta analysis , gastroenterology , liver fibrosis , subgroup analysis , fibrosis , nuclear medicine
Objectives The purpose of this study was to assess the performance of SuperSonic shear imaging (SuperSonic Imagine SA, Aix‐en‐Provence, France) for diagnosis of liver fibrosis. Methods Literature databases were searched to identify relevant studies from inception to February 28, 2015. Sensitivity, specificity, and other information were extracted from the studies. Pooled data were calculated by a bivariate mixed‐effects binary regression model. Subgroup and sensitivity analyses were performed. Publication bias was tested by funnel plots. Results Twelve studies were included in this meta‐analysis and reported on 1635 patients. The pooled sensitivity and specificity were 0.78 (95% confidence interval [CI], 0.69–0.85) and 0.95 (95% CI, 0.75–0.99), respectively, for fibrosis stages F≥1, 0.84 (95% CI, 0.81–0.86) and 0.81 (95% CI, 0.74–0.87) for F≥2, 0.89 (95% CI, 0.85–0.93) and 0.84 (95% CI, 0.77–0.89) for F≥3, and 0.88 (95% CI, 0.82–0.91) and 0.86 (95% CI, 0.81–0.90) for F=4. The areas under the summary receiver operating characteristic curves were 0.87 (95% CI, 0.84–0.90) for F≥1, 0.85 (95% CI, 0.81–0.88) for F≥2, 0.93 (95% CI, 0.91–0.95) for F≥3, and 0.93 (95% CI, 0.90–0.95) for F=4. No significant publication bias was found. Conclusions SuperSonic shear imaging could be used for staging of liver fibrosis. Especially, it has high diagnostic accuracy for severe fibrosis and cirrhosis.