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Prenatal Diagnosis and Perinatal Outcomes of Congenital Megalourethra
Author(s) -
Moaddab Amirhossein,
Sananes Nicolas,
Hernandez-Ruano Simone,
Werneck Britto Ingrid Schwach,
Blumenfeld Yair,
Stoll François,
Favre Romain,
Ruano Rodrigo
Publication year - 2015
Publication title -
journal of ultrasound in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 91
eISSN - 1550-9613
pISSN - 0278-4297
DOI - 10.7863/ultra.14.12064
Subject(s) - medicine , oligohydramnios , hydronephrosis , gestational age , fetus , retrospective cohort study , pregnancy , prenatal diagnosis , obstetrics , pediatrics , urinary system , surgery , genetics , biology
Objectives The purpose of this study was to evaluate the prenatal findings and postnatal outcomes in fetuses with congenital megalourethra. Methods This retrospective study reviewed our experience and the literature between 1989 and 2014. Prenatal findings were evaluated and compared with postnatal findings, including neonatal mortality and abnormal renal function (need for dialysis or renal transplantation). Results Fifty fetuses with congenital megalourethra were analyzed, including 6 cases diagnosed in our centers. Most cases (n = 43 [86.0%]) were diagnosed in the second trimester. Only 1 case was diagnosed in the first trimester, whereas 6 cases (12.0%) were diagnosed in the third trimester. Thirty‐five fetuses (70.0%) survived. Bilateral hydroureters were associated with perinatal death ( P = .024). Among the survivors, 41.9% of the neonates had renal impairment. The following factors were associated with postnatal renal impairment: presence of severe oligohydramnios/anhydramnios ( P = .033), bilateral hydronephrosis ( P = .008), and earlier gestational age at delivery ( P = .022). Conclusions In fetal megalourethra, bilateral hydroureters, bilateral hydronephrosis, and severe oligohydramnios/anhydramnios are associated with neonatal mortality and renal impairment.