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Optimization of Region of Interest Drawing for Quantitative Analysis
Author(s) -
Nakata Norio,
Ohta Tomoyuki,
Nishioka Makiko,
Takeyama Hiroshi,
Toriumi Yasuo,
Kato Kumiko,
Nogi Hiroko,
Kamio Makiko,
Fukuda Kunihiko
Publication year - 2015
Publication title -
journal of ultrasound in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 91
eISSN - 1550-9613
pISSN - 0278-4297
DOI - 10.7863/ultra.14.10042
Subject(s) - medicine
Objectives This study was performed to evaluate the diagnostic utility of quantitative analysis of benign and malignant breast lesions using contrast‐enhanced sonography. Methods Contrast‐enhanced sonography using the perflubutane‐based contrast agent Sonazoid (Daiichi Sankyo, Tokyo, Japan) was performed in 94 pathologically proven palpable breast mass lesions, which could be depicted with B‐mode sonography. Quantitative analyses using the time‐intensity curve on contrast‐enhanced sonography were performed in 5 region of interest (ROI) types (manually traced ROI and circular ROIs of 5, 10, 15, and 20 mm in diameter). The peak signal intensity, initial slope, time to peak, positive enhancement integral, and wash‐out ratio were investigated in each ROI. Results There were significant differences between benign and malignant lesions in the time to peak ( P < .05), initial slope ( P < .001), and positive enhancement integral ( P < .05) for the manual ROI. Significant differences were found between benign and malignant lesions in the time to peak ( P < .05) for the 5‐mm ROI; the time to peak ( P < .05) and initial slope ( P < .05) for the 10‐mm ROI; absolute values of the peak signal intensity ( P < .05), time to peak ( P < .01), and initial slope ( P < .005) for the 15‐mm ROI; and the time to peak ( P < .05) and initial slope ( P < .05) for the 20‐mm ROI. There were no statistically significant differences in any wash‐out ratio values for the 5 ROI types. Conclusions Kinetic analysis using contrast‐enhanced sonography is useful for differentiation between benign and malignant breast lesions.