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Acute Outflow Obstruction of Hepatic Veins in Rabbits
Author(s) -
Kim Kyoung Won,
Kim Pyo Nyun,
Shin Ji Hoon,
Shin Dong Ho,
Jeong Woo Kyoung,
Won Hyung Jin,
Shin Yong Moon,
Lee Won Jae,
Lee Moon Gyu,
Song Gi-Won,
Hwang Shin,
Lee Sung-Gyu
Publication year - 2011
Publication title -
journal of ultrasound in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 91
eISSN - 1550-9613
pISSN - 0278-4297
DOI - 10.7863/jum.2011.30.5.635
Subject(s) - medicine , nuclear medicine , bolus (digestion) , balloon , catheter , radiology , surgery
Objectives To compare time‐enhancement curve parameters of contrast‐enhanced sonography in acute partial hepatic venous outflow obstruction with those of a baseline study. Methods Contrast‐enhanced sonography was performed in 11 rabbits with bolus administration of a sulfur hexafluoride contrast agent (0.1 mL/kg). After baseline scanning for 3 minutes, a 5.3F balloon catheter was placed into the left hepatic vein. Obstruction was artificially induced by 0.4‐mL balloon inflation, and sonography was repeatedly performed thereafter. On images stored with 1‐second intervals, 2 × 2‐mm regions of interest were placed, and mean luminosity was measured. Time‐enhancement curves were plotted, and contrast arrival times, peak enhancement values, peak enhancement times, 50% wash‐out times, and 3‐minute wash‐out rates were obtained. Paired t tests were performed to evaluate the significance of differences in the parameters between baseline and obstruction. Results On baseline sonography, the median contrast arrival time, peak enhancement value, peak enhancement time, 50% wash‐out time, and 3‐minute wash‐out rate were 6 (range, 4–8; mean ± SD, 5.9 ± 1.2) seconds, 188.5 (104.7–209.5; 178.4 ± 33.1) arbitrary units, 19 (14–27; 19.8 ± 4.1) seconds, 75 (60–101; 78.2 ± 13.9) seconds, and 89.7% (81.3%–95.1%; 88.4% ± 4.9%), respectively. With obstruction, those values were 7 (5–12; 6.9 ± 2.3) seconds, 202.8 (98.2–215.1; 186.0 ± 39.3) arbitrary units, 31 (17–59; 32 ± 11.6) seconds, 101 (47–136; 96.2 ± 23.6) seconds, and 79.2% (66.2%–88.8%; 79.1% ± 7.6%). Compared with baseline, the peak enhancement time was significantly delayed from 19 to 31 seconds ( P = .0027), 50% wash‐out time significantly delayed from 75 to 101 seconds ( P = .0209), and 3‐minute wash‐out rate significantly decreased from 89.7% to 79.2% ( P < .0001) with obstruction, but there were no significant differences in contrast arrival times and peak enhancement values ( P = .0756 and .2179). Conclusions Contrast‐enhanced sonography can provide quantitative assessment of microbubble congestion in partial hepatic venous outflow obstruction. The peak enhancement time and 50% wash‐out time are delayed and 3‐minute wash‐out rate is decreased in rabbits with artificially induced obstruction compared with a baseline study.