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Use of Urokinase in Percutaneous Drainage of Large Breast Abscesses
Author(s) -
Berná-Serna Juan D.,
Berná-Mestre Juan D.,
Galindo Pedro J.,
Madrigal Manuel
Publication year - 2009
Publication title -
journal of ultrasound in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 91
eISSN - 1550-9613
pISSN - 0278-4297
DOI - 10.7863/jum.2009.28.4.449
Subject(s) - medicine , urokinase , saline , percutaneous , drainage , surgery , abscess , ecology , biology
Objective. The purpose of this study was to evaluate intracavitary urokinase therapy versus irrigation with a saline solution in percutaneous drainage of large breast abscesses. Methods. A prospective randomized study was conducted in 19 nonlactating women (median age, 35.7 years) with breast abscesses of greater than 3 cm. Percutaneous drainage with an ultrasound‐guided catheter was performed in group A patients (saline solution) and group B patients (urokinase). Postdrainage care and ultrasound‐guided drainage control were performed on an outpatient basis. The Student t test, Fisher exact test, χ 2 test, and Mann‐Whitney U test were used for statistical analysis. Results. Percutaneous drainage with saline or urokinase irrigation was successful in all cases. No statistically significant differences were observed between groups A and B for clinical parameters and sonographic characteristics of the abscesses. However, a statistically significant difference was observed between the two groups for the average drainage times ( P < 0.012), which were 3.8 days for the urokinase group and 5.3 days for the saline group. A recurrence was observed in 1 saline group patient who had a diagnosis of a chronic abscess, which was resolved with intracavitary urokinase irrigation. Conclusions. Percutaneous drainage of large breast abscesses in nonlactating women with intracavitary urokinase irrigation is a simple and safe procedure. It reduces the treatment time and improves the clinical course of patients more than conventional drainage with saline irrigation.