Premium
Effect of Hyperbaric Oxygen on Flow‐Mediated Vasodilation
Author(s) -
Saglam Mutlu,
Bozlar Ugur,
Kantarci Fatih,
Ay Hakan,
Battal Bilal,
Coskun Unsal
Publication year - 2008
Publication title -
journal of ultrasound in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 91
eISSN - 1550-9613
pISSN - 0278-4297
DOI - 10.7863/jum.2008.27.2.209
Subject(s) - medicine , brachial artery , cuff , anesthesia , vasodilation , surgery , cardiology , blood pressure
Objective The purpose of this study was to investigate the effect of hyperbaric oxygen (HBO) treatment on flow‐mediated vasodilation (FMD) by ultrasound examination. Methods We studied 14 young patients without cardiovascular problems who underwent HBO treatment. The indications for HBO treatment were osteomyelitis (n = 8), Crohn disease (n = 2), perianal abscesses (n = 2), lingual artery embolization (n = 1), and aseptic necrosis (n = 1). The ultrasound evaluation for FMD was performed before HBO treatment, after 1 session of HBO treatment, and after 10 sessions of HBO treatment. The right brachial artery FMD response was evaluated by the mean of the baseline right brachial artery diameter, absolute change in the diameter before and after cuff inflation/deflation, and percent change in the diameter. Results Statistical analysis showed a significant change in the preinflation right brachial artery diameter before (mean ± SD, 3.6 ± 0.54 mm) and after (3.76 ± 0.56 mm) 10 sessions of HBO treatment ( P < .05). The absolute changes in the right brachial artery diameter before and after cuff inflation/deflation (0.36 ± 0.2 mm before HBO treatment, 0.37 ± 0.22 mm after 1 session of HBO treatment, and 0.38 ± 0.21 mm after 10 sessions) and percent change in FMD (10% ± 5.8% before HBO treatment, 10.6% ± 7.5% after 1 session of HBO treatment, and 10.6% ± 7.7% after 10 sessions) after induction of a hyperemic response by cuff inflation were not statistically significant ( P > .05). Conclusions Hyperbaric oxygen treatment did not have an immediate effect on FMD (absolute change in the right brachial artery diameter after cuff inflation/deflation); however, the right brachial artery diameter increased after 10 sessions of HBO treatment. This may suggest chronic stress on the vascular endothelium after HBO.