Premium
Fetal Transcerebellar Diameter Measurement for Prediction of Gestational Age at the Extremes of Fetal Growth
Author(s) -
Chavez Martin R.,
Ananth Cande V.,
Smulian John C.,
Vintzileos Anthony M.
Publication year - 2007
Publication title -
journal of ultrasound in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 91
eISSN - 1550-9613
pISSN - 0278-4297
DOI - 10.7863/jum.2007.26.9.1167
Subject(s) - medicine , fetus , gestational age , fetal growth , obstetrics , parity (physics) , pregnancy , physics , particle physics , genetics , biology
Objectives The purpose of this study was to determine the accuracy of our previously published and prospectively validated transcerebellar diameter (TCD) nomogram in the prediction of gestational age (GA) in intrauterine growth‐restricted (IUGR) and large fetuses. Methods We established a cross‐sectional nomogram of TCD in 24,026 well‐dated singleton fetuses and prospectively validated the nomogram using 2597 fetuses from a separate population. This nomogram was validated in both IUGR (n = 55) and large (n = 16) fetuses (estimated fetal weight, <10th and >90th percentiles, respectively). The actual GA was subtracted from the TCD‐predicted GA in IUGR and large fetuses, and the concordance between the actual and predicted GAs was assessed using the Pearson correlation coefficient. Results Concordance between the actual and predicted GA based on our previously published singleton TCD nomogram was high for both IUGR and large fetuses (Pearson correlation, r = 0.98 and 0.95, respectively; P < .001). The means (SDs) of actual and predicted GA based on TCD in IUGR fetuses were 24.9 (6.5) and 25.1 (6.3) weeks, respectively. The predicted GA based on TCD in IUGR fetuses was within 3 days in 97.5% in the second trimester and 93.3% in the third trimester. In large fetuses, the difference between the actual and predicted GA based on TCD within 3 days was 100% in both the second and third trimesters. Conclusions This study shows that our institution‐specific TCD nomogram is reliable and accurate in predicting GA even at extremes of fetal growth.