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Development of an Electrophysiology (EP)‐Enabled Intracardiac Ultrasound Catheter Integrated With NavX 3‐Dimensional Electrofield Mapping for Guiding Cardiac EP Interventions
Author(s) -
Li Xiao Kui,
Pemberton James,
Thomenius Kai,
Dentinger Aaron,
Lowe Robert I.,
Ashraf Muhammad,
Shung K. Kirk,
Chia Raymond,
Stephens Douglas N.,
O'Donnell Matthew,
Mahajan Aman,
Balaji Seshadri,
Shivkumar Kalyanam,
Sahn David J.
Publication year - 2007
Publication title -
journal of ultrasound in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 91
eISSN - 1550-9613
pISSN - 0278-4297
DOI - 10.7863/jum.2007.26.11.1565
Subject(s) - medicine , catheter , intracardiac injection , ablation , catheter ablation , cardiology , pulmonary vein , cardiac electrophysiology , cardiac ablation , femoral vein , radiology , electrophysiology
Objectives We have developed an integrated high‐resolution intracardiac echocardiography (ICE) catheter for electrophysiology (EP) testing, which can be coregistered in 3‐dimensional space with EP testing and ablation catheters using electrofield sensing. Methods Twelve open‐chest pigs (34–55 kg) and 3 closed‐chest pigs were studied. After introduction from the jugular or femoral venous locations, the 9F side‐looking, highly steerable (0°–180°), 64‐element array catheters could be manipulated easily throughout the right side of the heart. Multisite cardiac pacing was performed for assessing left ventricular (LV) synchrony using tissue Doppler methods. Also, in the open‐chest pigs, right atrial (RA) and right ventricular (RV) ablations were performed with a separate radio frequency catheter under fluoroscopic guidance and visualized with ICE to characterize the changes. In the 3 closed‐chest pigs, electrofield NavX 3‐dimensional coregistration (St Jude Medical Corp, Minneapolis, MN) allowed us to test whether this additional feature could shorten the time necessary to perform 4 targeted ablations in each animal while imaging the ablation catheter and the adjacent region by ICE. Results Intracardiac anatomy, tricuspid, aortic, pulmonary, and mitral valve function, and pulmonary vein flow were all imaged reproducibly from scanning locations in the RA or RV in all animals, along with assessment of cardiac motion and the effects of multisite pacing. Three‐dimensional electrofield displays detailed the spatial relationship between the ICE catheter and ablation catheters such that the time to visualize and ablate 4 sites in each of the 3 closed‐chest animals was reduced. Conclusions This new technology is a first step in the integration of ICE with EP procedures.