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Intrauterine Growth Restriction and Placental Location
Author(s) -
Kalanithi Lucy E. G.,
Illuzzi Jessica L.,
Nossov Vladimir B.,
Frisbæk Yr,
Abdel-Razeq Sonya,
Copel Joshua A.,
Norwitz Errol R.
Publication year - 2007
Publication title -
journal of ultrasound in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 91
eISSN - 1550-9613
pISSN - 0278-4297
DOI - 10.7863/jum.2007.26.11.1481
Subject(s) - placentation , medicine , obstetrics , intrauterine growth restriction , odds ratio , gestational age , pregnancy , confidence interval , gestation , small for gestational age , exact test , logistic regression , confounding , percentile , gynecology , placenta , fetus , statistics , genetics , mathematics , biology
Objectives The purpose of this study was to determine whether an association exists between intrauterine growth restriction (IUGR) and second‐trimester placental location. Methods A case‐control study was performed in well‐dated singleton pregnancies with (n = 67) and without (n = 205) IUGR (defined as estimated fetal weight <10th percentile for gestational age at the last sonographic examination) to investigate the association between IUGR and placental location. Placental location was determined by sonography at 16 to 20 weeks' gestation. Maternal, perinatal, and delivery characteristics were abstracted from medical records. Group comparisons were made by the Student t test, χ 2 analysis, the Fisher exact test, the Wilcoxon test, and analysis of variance. Multivariable logistic regression analysis was used to determine the relationship between IUGR and placental location. Results In both groups, the most common placental locations in the second trimester were anterior and posterior. After adjusting for potential confounders (including race, chronic hypertension, and hypertensive disorders of pregnancy), IUGR pregnancies were nearly 4‐fold more likely to have lateral placentation (odds ratio, 3.8; 95% confidence interval, 1.3–11.2) compared with anterior or posterior placentation. Conclusions Pregnancies complicated by IUGR are significantly more likely than non‐IUGR pregnancies to have lateral placentation in the second trimester.