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Three‐Dimensional Quantification of Tumor Vascularity as a Tertiary Test After B‐Mode and Power Doppler Evaluation for Detection of Ovarian Cancer
Author(s) -
Guerriero Stefano,
Ajossa Silvia,
Piras Silvia,
Gerada Marta,
Floris Stefano,
Garau Nicoletta,
Minerba Luigi,
Paoletti Anna Maria,
Melis Gian Benedetto
Publication year - 2007
Publication title -
journal of ultrasound in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 91
eISSN - 1550-9613
pISSN - 0278-4297
DOI - 10.7863/jum.2007.26.10.1271
Subject(s) - medicine , vascularity , receiver operating characteristic , cutoff , radiology , doppler effect , nuclear medicine , adnexal mass , power doppler , duplex ultrasonography , color doppler , ultrasonography , physics , quantum mechanics , astronomy
Objectives The purpose of this study was to investigate the role of 3‐dimensional (3D) quantification of tumor vascularity in the differential diagnosis of pelvic indeterminate masses with a solid appearance or unilocular or multilocular cysts with a solid component showing central vascularization on 2‐dimensional power Doppler sonography. Methods One hundred fifty‐seven consecutive pelvic masses in 153 patients were included in this study and underwent sonography before surgery. Masses that showed a typical benign pattern on B‐mode sonography (n = 112) and indeterminate masses with peripheral or absent flow on power Doppler sonography (n = 10) were not evaluated by 3D sonography. Only masses with central vascularization were submitted to 3D power Doppler imaging (n = 35). The following 3D vascular parameters were calculated: relative color and flow measure (similar to the vascularization flow index obtained with other systems). Results With receiver operating characteristic curve analysis, the best cutoff values for relative color and flow measure were 4.4 and 2.7, respectively. Flow measure had sensitivity of 68% and specificity of 40% in the overall population submitted to 3D power Doppler sonography. Accuracy slightly increased when masses with small papillary projections (<10 mL) were excluded. In this group (n = 22), sensitivity was 83%, and specificity was 50%. Conclusions In masses with central vascularization on 2‐dimensional power Doppler sonography, the use of 3D quantification of tumor vascularity had low diagnostic accuracy in the detection of adnexal malignancies, although an increase in accuracy in masses with a solid portion of greater than 10 mL was reported.