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Echo Contrast‐Enhanced Power Doppler Ultrasonography for Assessment of Angiogenesis in Renal Cell Carcinoma
Author(s) -
Kabakci Neslihan,
Igci Enis,
Secil Mustafa,
Yorukoglu Kutsal,
Mungan Ugur,
Celebi Ilhan,
Kirkali Ziya
Publication year - 2005
Publication title -
journal of ultrasound in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 91
eISSN - 1550-9613
pISSN - 0278-4297
DOI - 10.7863/jum.2005.24.6.747
Subject(s) - medicine , power doppler , angiogenesis , radiology , renal cell carcinoma , contrast (vision) , doppler effect , ultrasonography , lesion , nuclear medicine , pathology , artificial intelligence , computer science , physics , astronomy
Objective Tumoral growth is an angiogenesis‐dependent event. Although there are studies about the importance of histopathologic angiogenesis in various malignancies, the assessment of the angiogenesis by radiologic techniques is not well established. The aim of this study was to investigate the efficacy of echo contrast‐enhanced power Doppler ultrasonography (PDUS) in determining the angiogenic status of renal cell carcinoma (RCC). Methods Power Doppler ultrasonography was performed before and after intravenous administration of an echo contrast agent in 42 patients with renal masses. Twenty‐one of these renal masses were diagnosed as RCC histopathologically, and these 21 patients were reevaluated retrospectively. The color pixel ratios of selected images were calculated as the ratio of the number of pixels showing power Doppler signals to the total number of pixels within the lesion. The results were compared with the histopathologic microvessel density (MVD). Results A significant correlation was found between color pixel ratio and MVD values in both PDUS techniques. The use of the echo contrast agent improved this correlation and P values (Spearman ρ from 0.436 to 0.551; P from .048 to .01). Conclusions Color pixel ratio values reflect the MVD in RCC. Therefore, these results suggest that preoperative quantification of angiogenesis can be possible with the help of PDUS in RCC.