Premium
Sonographic and Doppler characteristics of the corpus luteum: can they predict pregnancy outcome?
Author(s) -
Frates M C,
Doubilet P M,
Durfee S M,
Di Salvo D N,
Laing F C,
Brown D L,
Benson C B,
Hill J A
Publication year - 2001
Publication title -
journal of ultrasound in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 91
eISSN - 1550-9613
pISSN - 0278-4297
DOI - 10.7863/jum.2001.20.8.821
Subject(s) - corpus luteum , medicine , pregnancy , gestation , obstetrics , prospective cohort study , gynecology , ovary , genetics , biology
To determine whether there is a relationship between gray scale or Doppler characteristics of the corpus luteum and first‐trimester pregnancy outcome. We conducted a prospective study of patients with spontaneous singleton pregnancies between 5 and 8 weeks' gestation. The corpus luteum size, sonographic appearance, resistive index, and peak systolic velocity were measured on transvaginal sonography. Maternal use of exogeneous progesterone was recorded. Only patients with known first‐trimester outcome were included. There were 201 study patients. The corpus luteum could be visualized in 197 (98%) and had a mean +/‐ SD size of 1.9 +/‐ 0.6 cm, a mean resistive index of 0.50 +/‐ 0.08, and a peak systolic velocity of 20.5 +/‐ 11.2 cm/s. There were 151 first‐trimester survivors (75.1 %) and 50 spontaneous losses (24.9%). In a comparison of the survivors and losses, there was no significant difference in mean corpus luteum size (1.9 versus 1.7 cm; P = .10, t test), mean resistive index (0.50 versus 0.50; P = .71, t test), peak systolic velocity (21 versus 19 cm/s; P = .29, t test), or sonographic appearance (P = .78, chi2 test). The lack of association between corpus luteum characteristics and outcome persisted when cases were stratified by progesterone use and the presence or absence of a heartbeat on the study sonogram. There is no apparent relationship between the characteristics of the corpus luteum and first‐trimester pregnancy outcome.