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Quantifying B‐mode images of in vivo rat mammary tumors by the frequency dependence of backscatter.
Author(s) -
Topp K A,
Zachary J F,
O'Brien W D
Publication year - 2001
Publication title -
journal of ultrasound in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 91
eISSN - 1550-9613
pISSN - 0278-4297
DOI - 10.7863/jum.2001.20.6.605
Subject(s) - backscatter (email) , medicine , in vivo , amplitude , consistency (knowledge bases) , frequency dependence , biomedical engineering , mammary gland , pathology , radiology , optics , nuclear magnetic resonance , cancer , physics , biology , telecommunications , geometry , microbiology and biotechnology , mathematics , breast cancer , computer science , wireless
To evaluate the frequency dependence of ultrasonic backscatter for its ability to differentiate between neoplastic and healthy tissue. Standard B‐mode images were created of 5 rats with spontaneous mammary tumors, and regions of interest in the lesion and surrounding tissue were parameterized by the slope of the backscatter amplitude versus frequency. In 4 of the 5 rats, the averaged backscatter slope of the regions of interest in the tumor was significantly (P < .05) different from that of the surrounding tissue, and the fifth case had a moderate difference (P = .20). The consistency of the averaged slope values (1.2‐1.8 dB/MHz) across all but 1 of the mammary tumors was encouraging for the prospect of identifying a tissue type by its backscatter slope. This work suggests that characterization and diagnosis of tissue types may be possible by using ultrasonographic images quantified by the frequency dependence of backscatter.