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Dodecafluoropentane ultrasonic contrast enhancement in carotid diagnosis: preliminary results.
Author(s) -
Gahn G,
Ackerman R H,
Candia M R,
Barrett K M,
Lev M H,
Huang A Y
Publication year - 1999
Publication title -
journal of ultrasound in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 91
eISSN - 1550-9613
pISSN - 0278-4297
DOI - 10.7863/jum.1999.18.2.101
Subject(s) - medicine , ultrasonic sensor , carotid arteries , ultrasound , color doppler , radiology , carotid bifurcation , doppler effect , contrast (vision) , saline , common carotid artery , ultrasonography , biomedical engineering , optics , physics , astronomy
To assess the efficacy in carotid diagnosis of an investigational dodecafluoropentane ultrasonic contrast enhancing agent, we compared B‐mode, color flow, and duplex Doppler findings in 16 patients with common carotid artery bifurcation disease after dodecafluoropentane and saline injections. Dodecafluoropentane produced enhanced backscatter in all patients for 4 to 20 min (mean, 8.4+/‐4.74 min) after intravenous injection. In six patients this enhancement improved the color flow and pulsed Doppler signal detection in areas of sonographic shadowing. The enhanced color flow information changed the diagnostic impression in one case. Dodecafluoropentane produced enhanced backscatter in the carotid artery in all patients, and for a mean duration longer than that reported for other agents. It has the potential to improve the efficacy of carotid ultrasonic evaluation.