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Fetal biometry of skeletal dysplasias: a multicentric study.
Author(s) -
Goncalves L,
Jeanty P
Publication year - 1994
Publication title -
journal of ultrasound in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 91
eISSN - 1550-9613
pISSN - 0278-4297
DOI - 10.7863/jum.1994.13.12.977
Subject(s) - achondroplasia , osteogenesis imperfecta , medicine , osteochondrodysplasia , dysplasia , fetus , gestational age , pediatrics , pregnancy , anatomy , genetics , biology
Twenty‐three diagnostic centers worldwide contributed 127 cases of 17 skeletal dysplasias. Discriminant analysis showed that the femur length was the best biometric parameter to distinguish among the five most common disorders in this series (thanatophoric dysplasia, osteogenesis imperfecta type II, achondrogenesis, achondroplasia and hypochondroplasia). Fifty‐four percent of fetuses with femur length below 30% of the mean for gestational age had achondrogenesis. Seventy‐eight percent of measurements between 40 and 60% of the mean for gestational age represented either thanatophoric dysplasia or osteogenesis imperfecta type II. Fetuses who had over 80% of the mean for gestational age had predominantly hypochondroplasia, achondroplasia, and osteogenesis imperfecta type III.