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Sister chromatid exchange analysis of human cells exposed to diagnostic levels of ultrasound.
Author(s) -
Martin A O,
Madsen E L,
Dyer A R,
White L,
Bouck N P,
Sabbagha R E,
Hermanoff M,
Chen J M,
Ludtke L J
Publication year - 1991
Publication title -
journal of ultrasound in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 91
eISSN - 1550-9613
pISSN - 0278-4297
DOI - 10.7863/jum.1991.10.12.665
Subject(s) - medicine , sister chromatid exchange , theophylline , ultrasound , ultrasonography , sister chromatids , lymphocyte , diagnostic ultrasound , lymphoblast , ultrasonic sensor , in vitro , andrology , pathology , cell culture , surgery , radiology , genetics , gene , chromosome , biology
Lymphocyte and lymphoblastoid cells were exposed in vitro to diagnostic levels of ultrasonic beams delivered by a Hewlett‐Packard CE 30001 and a GE system with a 5 MHz linear transducer for 20 sec, 1 min, 5 min, and 20 min. Temperature and cavitation effects were controlled and there were matched sham exposures. The synergistic effects of theophylline with ultrasonography also were investigated. Small increases in sister chromatid exchange levels were observed after ultrasonic exposure, but increases were so small as to be unlikely to have clinical relevance. Theophylline was found to have no effect and ultrasonography had no effect on cell viability.