Open AccessCritical Level of Alanine Transaminase to Predict Foetomaternal Outcome in Intrahepatic Cholestasis of Pregnancy: A Case-control Study
Author(s) -
Nidhi Ahuja,
Dabral Anjali,
Sheeba Marwah,
Rekha Bharti,
Deepti Pachauri,
Jyotsna Suri
Publication year - 2021
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2021/49078.14904
Subject(s) - medicine , aspartate transaminase , gastroenterology , cholestasis , alanine transaminase , meconium , incidence (geometry) , gestational age , pregnancy , bile acid , transaminase , obstetrics , alkaline phosphatase , fetus , chemistry , biology , biochemistry , physics , optics , genetics , enzyme
Intrahepatic Cholestasis of Pregnancy (IHCP) is a disorder of the second and third trimester causing pruritis without a rash in the women. To avoid the adversities, early delivery is indicated before serum bile acids levels of >40 μmol/L is reached. In the settingswhere bile acid testing is not available, serum transaminases can be used for diagnosis and management of IHCP. Aim: To find out value of Alanine Transaminase (ALT) for the prediction of adverse outcomes. Materials and Methods: This case-control study was carried out from October 2018 to March 2020, enrolled 75 singleton women with IHCP and 75 controls in their third trimester. The diagnosis was based on the presence of pruritis without an identifiable dermatological cause along with raised serum transaminases. Serum ALT levels and the foetomaternal outcomes were noted. Statistical analysis was done using Statistical Package for Social Sciences (SPSS) version 21.0. Mann-Whitney test, Chi-square test and Fisher’s exact test were used to compare all variables. The p-value of 133 U/L is predictive of adverse foetal outcome, therefore, termination of pregnancy can be advocated above this level.