Open AccessSarcoidosis and Primary Biliary Cholangitis- An Overlap
Author(s) -
Akshatha Manohar,
Jayashankar CA,
Nithin Kumar,
P. Sharmila Bhanu,
Prathima Shivaji Rao
Publication year - 2021
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2021/49016.15101
Subject(s) - sarcoidosis , medicine , liver biopsy , biopsy , serology , primary biliary cirrhosis , cutaneous sarcoidosis , primary sclerosing cholangitis , pathology , systemic disease , disease , dermatology , immunology , antibody
Primary Biliary Cholangitis (PBC) is a chronic progressive autoimmune cholestatic liver disease. Sarcoidosis is a multisystem chronic granulomatous disease. Both diseases are known to affect the liver causing granulomas. Sarcoidosis commonly involves the skin while PBC is associated with autoimmune skin disorders. Diagnosis of PBC requires biochemical, serological and histological confirmation. Steroids are used in the treatment of sarcoidosis. The role of steroids in the treatment of PBC is not completely established. In this case report, authors present the case of a 31-years-old female diagnosed as sarcoidosis based on granulomatous lesions in skin biopsy with concurrent PBC diagnosed on basis of serology and liver biopsy.