Open AccessOld Wine in a New Bottle: Acromegaly Presenting as Diabetic Ketoacidosis
Author(s) -
Sowrabha Bhat,
Subhodip Pramanik,
Pradip Mukhopadhyay,
Subhankar Chowdhury
Publication year - 2021
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2021/48795.15099
Subject(s) - acromegaly , medicine , diabetic ketoacidosis , diabetes mellitus , ketoacidosis , endocrinology , insulin resistance , complication , insulin , pediatrics , growth hormone , hormone , type 1 diabetes
Acromegaly is a rare disease characterised by chronic excess of Growth Hormone (GH) levels. Insulin signalling is impaired, gluconeogenesis is excess and peripheral insulin resistance is increased in acromegaly causing hyperglycaemia and diabetes. Diabetic Ketoacidosis (DKA) is a rare but known complication of diabetes in acromegaly. Most cases of acromegaly come into light due to the classical soft tissue changes in the face and extremities. A high index of suspicion is required to diagnose this condition in early stage. Here, a case of 22-years-old male presented with DKA and on investigation was found to have acromegaly due to a GH secreting pituitary macroadenoma. This management and subsequent follow-up of the case along with review of literature is also done. Such a presentation of acromegaly was rare but rewarding.