Open AccessReview of Latest Potential Treatment Modalities in SARS-CoV-2
Author(s) -
Pratyush Kumar,
Shivani Tyagi
Publication year - 2021
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2021/47173.14736
Subject(s) - medicine , intensive care medicine , ards , disease , modalities , coronavirus , pandemic , acute respiratory distress , therapeutic modalities , asymptomatic , immunology , covid-19 , lung , infectious disease (medical specialty) , social science , sociology
The ongoing Coronavirus Disease-2019 (COVID-19) pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) can cause illnesses that vary from asymptomatic or paucisymptomatic conditions to Acute Respiratory Distress Syndrome (ARDS) or respiratory failure requiring ventilator support or sepsis and multiple organ dysfunction syndromes. Timely treatment and appropriate management of COVID-19 diseased patients is crucial to curb the morbidity and mortality rates. Much of the research is focused on formulating preventive and therapeutic strategies based on the complex pathophysiology of this disease. New drugs targeting viral entry into host cells, inhibiting viral Proteases, viral RNA Polymerases (RdRp), transport channels, and the drugs with multicentric action, immunomodulators and adjuvants are being researched upon. Other management modalities like regenerative medicine and the use of convalescent plasma therapy have been explored. This review is aimed at the therapeutic aspects of the treatment and management modalities.