Open AccessDetection of blaCTX-M Extended Spectrum Betalactamase Producing Salmonella enterica Serotype Typhi in a Tertiary Care Centre
Author(s) -
Anand Ramachandran,
M Shanthi,
Uma Sekar
Publication year - 2017
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2017/30150.10637
Subject(s) - cefotaxime , microbiology and biotechnology , cephalosporin , ceftriaxone , biology , salmonella , ceftazidime , ampicillin , ciprofloxacin , agar dilution , salmonella typhi , multiple drug resistance , minimum inhibitory concentration , drug resistance , virology , antimicrobial , antibiotics , bacteria , pseudomonas aeruginosa , gene , genetics , escherichia coli
Infections caused by Salmonella are an important public health threat in tropical and subtropical countries. Due to the emergence of resistance to ampicillin, chloramphenicol and trimethoprim/sulfamethoxazole (multidrug resistant salmonellae) in the late 1980s, fluoroquinolones and extended spectrum cephalosporins became the drugs of choice. Resistance to cefotaxime and ceftriaxone due to the production of Extended Spectrum Beta-Lactamase (ESBL) and reduced susceptibility to ciprofloxacin have emerged resulting in treatment failure. The Cefotaximase (CTX-M) type ESBLs are the most widespread beta lactamase among Enterobacteriaceae including salmonellae.