Open AccessPrognostic Significance of Epidermal Growth Factor Receptor in Patients of Glioblastoma Multiforme
Author(s) -
Kalpalata Tripathy,
Bidyutprava Das,
Ajit Kumar Singh,
Aparajita Misra,
Sanjib Misra,
Sudhansu Sekhar Misra
Publication year - 2017
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2017/30138.10327
Subject(s) - temozolomide , epidermal growth factor receptor , medicine , immunohistochemistry , glial fibrillary acidic protein , pathology , oncology , radiation therapy , proliferation index , pleomorphism (cytology) , biopsy , cancer
Glioblastoma Multiforme (GBM) is the most aggressive glial tumour with hallmark characteristics of rampant proliferation of glial cells along with high pleomorphism, necrosis, endothelial proliferation and high MIB-1 labeling index (cell proliferation marker). These tumours are managed by surgery followed by Radiotherapy (RT), Chemotherapy (CT) and adjuvant CT Temozolomide (TMZ).