Open AccessExpression of p16INK4A Protein in Cervical Intraepithelial Neoplasia and Invasive Carcinoma of Uterine Cervix
Author(s) -
Vatsala Kishore
Publication year - 2017
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2017/29394.10644
Subject(s) - cervical intraepithelial neoplasia , medicine , dysplasia , cervical cancer , immunohistochemistry , hpv infection , malignancy , pathology , biomarker , cervix , adenocarcinoma , cancer , carcinoma , intraepithelial neoplasia , oncology , biology , prostate cancer , biochemistry
Cervical cancer still ranks as the most frequent cancer among women in India. Infection with Human Papilloma Virus (HPV) results in precancerous lesions and invasive cervical cancer. Interaction of HPV oncogenic proteins with cellular regulatory proteins leads to upregulation of p16INK4A, a cyclin dependent kinase inhibitor. Therefore, p16INK4A overexpression is a surrogate biomarker of HPV infection making it useful in evaluating HPV associated premalignant and malignant lesions of gynaecological tract.