Open AccessMRI in Chemotherapy induced Leukoencephalopathy: Report of Two Cases and Radiologist’s Perspective
Author(s) -
Geetika Sindhwani,
Manali Arora,
Vishal Thakker,
Abhinav Jain
Publication year - 2017
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2017/29164.10248
Subject(s) - leukoencephalopathy , medicine , white matter , methotrexate , chemotherapy , radiology , progressive multifocal leukoencephalopathy , diffusion mri , radiological weapon , pathology , magnetic resonance imaging , surgery , psychiatry , multiple sclerosis
Leukoencephalopathy is a progressive white matter disease primarily caused due to myelin damage by a variety of factors. Chemotherapy for oncological treatment is an uncommon but important cause of potentially reversible leukoencephalopathy. In current radiological setting, conventional and diffusion weighted MRI play a significant role in early and accurate detection of this entity. We are hereby presenting MRI evaluation of two cases of methotrexate and 5-fluorouracil induced toxic leukoencephalopathy.