Focal Adhesion Kinase Expression in Ameloblastoma: A Preliminary Observational Study | Zendy

Snehal Patil | Zendy

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Focal Adhesion Kinase Expression in Ameloblastoma: A Preliminary Observational Study

Author(s) -

Snehal Patil

Publication year - 2017

Publication title -

journal of clinical and diagnostic research

Language(s) - English

Resource type - Journals

eISSN - 2249-782X

pISSN - 0973-709X

DOI - 10.7860/jcdr/2017/28895.10064

Subject(s) - focal adhesion , ameloblast , ameloblastoma , immunohistochemistry , pathology , hepatic stellate cell , cytoplasm , epithelium , odontogenic tumor , biology , microbiology and biotechnology , medicine , lesion , signal transduction , anatomy , enamel paint , dentistry , maxilla

Focal Adhesion Kinase (FAK) is a membrane-associated molecule, which plays a major role in tumourigenesis by promoting cell survival, proliferation, migration, and invasion. Hence, FAK is a well known molecule that has been targeted therapeutically for the treatment of various malignancies. Ameloblastoma (AB) is a locally invasive, destructive and recurrent benign odontogenic lesion. Based on these properties, we have hypothesized that odontogenic epithelium of AB could show increased expression of FAK.

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