Open AccessFocal Adhesion Kinase Expression in Ameloblastoma: A Preliminary Observational Study
Author(s) -
Shankargouda Patil,
Sarode Gs,
Sarode Sc,
Rahul Anand
Publication year - 2017
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2017/28895.10064
Subject(s) - focal adhesion , ameloblast , ameloblastoma , immunohistochemistry , pathology , hepatic stellate cell , cytoplasm , epithelium , odontogenic tumor , biology , microbiology and biotechnology , medicine , lesion , signal transduction , anatomy , enamel paint , dentistry , maxilla
Focal Adhesion Kinase (FAK) is a membrane-associated molecule, which plays a major role in tumourigenesis by promoting cell survival, proliferation, migration, and invasion. Hence, FAK is a well known molecule that has been targeted therapeutically for the treatment of various malignancies. Ameloblastoma (AB) is a locally invasive, destructive and recurrent benign odontogenic lesion. Based on these properties, we have hypothesized that odontogenic epithelium of AB could show increased expression of FAK.