Open AccessImmunohistochemical Expression of Cyclo-oxygenase 2 and Liver X Receptor-α in Acne Vulgaris
Author(s) -
Ola Ahmed Bakry,
Shawky Mahmoud El Farargy,
Noha Nour El Din El Kady,
Hend Farag Abu Dawy
Publication year - 2017
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2017/28754.10577
Subject(s) - acne , papulopustular , immunohistochemistry , liver x receptor , medicine , epidermis (zoology) , endocrinology , pathology , dermatology , transcription factor , biology , gene , nuclear receptor , biochemistry , anatomy , rosacea
Acne Vulgaris (AV) is a common inflammatory disease of pilosebaceous units. Liver X Receptor-α (LXR-α) is a ligand activated transcription factor. It controls transcription of genes involved in lipid and fatty acid synthesis. Cyclo-oxygenase 2 (COX2) is a rate limiting enzyme in prostaglandin synthesis. It plays important role in inflammation.