Open AccessIntracarotid Sodium Nitroprusside on Fifth Post Ischemic Stroke Day in Middle Cerebral Artery Occlusion Rat Model
Author(s) -
Vinod Kumar Tewari,
Vivek Bhosale,
Rakesh Shukla,
Hari Kishan Das Gupta,
Sheeba
Publication year - 2017
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2017/28085.10504
Subject(s) - sodium nitroprusside , medicine , internal carotid artery , anesthesia , middle cerebral artery , occlusion , saline , nitric oxide , ischemia , common carotid artery , nitric oxide synthase , stroke (engine) , carotid arteries , mechanical engineering , engineering
Ischemic stroke at later stages (>4.5 hour) have very few treatment options left. In those cases Nitric Oxide (NO) may provide promising results. NO is active in signaling pathways. Sodium Nitroprusside (SNP), a NO donor was tested earlier in rat Middle Cerebral Artery Occlusion (MCAO) model in early stages (5-60 minutes) and found useful but in delayed stroke cases (60-120 minutes) found useless. This was due to local inducible Nitric Oxide Synthase Enzyme (iNOS) and superoxide (causes destructive effect) formation which was skipped.