Open AccessEvaluation of Tumour Associated Macrophages and Angiogenesis in Ameloblastoma
Author(s) -
Akinyele Olumuyiwa Adisa,
Samuel Ebele Udeabor,
Anna Orłowska,
Robert Sader,
Shahram Ghanaati
Publication year - 2017
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2017/28067.10568
Subject(s) - ameloblastoma , cd34 , angiogenesis , cd68 , pathology , immunohistochemistry , monoclonal antibody , antibody , metastasis , biology , antigen , macrophage , cancer research , medicine , cancer , immunology , anatomy , stem cell , microbiology and biotechnology , maxilla , biochemistry , in vitro
Ameloblastoma is a locally invasive odontogenic neoplasm that has a high recurrence rate. The invasion of adjacent tissue is supported by angiogenesis stimulated by Tumour-Associated Macrophages (TAMs). TAMs are macrophages modified in the milieu of the tumour microenvironment and have very weak or no ability to present antigens. Thus, there is collaboration between the tumour and the tumour microenvironment to maintain tumour enlargement. TAMs exist as the classically activated M1 macrophages that possess antitumour activity and the otherwise activated M2 macrophages that support tumour invasion and metastasis.