Open AccessVariations of Adipokines and Insulin Resistance in Primary Hypothyroidism
Author(s) -
Kaushik Kar,
Satwika Sinha
Publication year - 2017
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2017/26666.10345
Subject(s) - medicine , endocrinology , adipokine , adiponectin , leptin , insulin resistance , insulin , hormone , homeostatic model assessment , adipose tissue , obesity
Hypothyroidism is a common concern in endocrinology practice, which plays a significant role in metabolic and development processes. Obesity, hyperlipidaemia and hypertension may complicate hypothyroidism. Recent studies have shown that cytokines like leptin and adiponectin, secreted by adipose tissue and exert their endocrinal functions by modulating appetite, obesity and insulin sensitivity in conjunction with thyroid hormones. Interrelation between thyroid hormone, insulin resistance and adipokines are not yet clear.