Open AccessClinical Efficacy and Safety on Combining 20% Trichloroacetic Acid Peel with Topical 5% Ascorbic Acid for Melasma
Author(s) -
Surabhi Dayal,
Priyadarshini Sahu,
Manoj Kumar Yadav,
Vijay Kumar Jain
Publication year - 2017
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2017/26078.10685
Subject(s) - melasma , ascorbic acid , trichloroacetic acid , medicine , dermatology , hyperpigmentation , quality of life (healthcare) , clinical trial , chemistry , food science , biochemistry , nursing
Trichloroacetic Acid (TCA) is a versatile peeling agent for treatment of melasma. However, Post-Inflammatory Hyperpigmentation (PIH) is reported to be the most common side-effect associated with TCA peel. Topical Ascorbic Acid (AA) due to its effect as antioxidant and tyrosinase inhibitor helps to prevent PIH and maintains the response.