Open AccessDetermination and Validation of a Lower Cut Off Value of Cerebrospinal Fluid Adenosine Deaminase (CSF-ADA) Activity in Diagnosis of Tuberculous Meningitis
Author(s) -
Raviraj,
Renoy A Henry,
G Ganapathi Rao
Publication year - 2017
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2017/25823.9625
Subject(s) - tuberculous meningitis , adenosine deaminase , medicine , cerebrospinal fluid , meningitis , area under curve , receiver operating characteristic , tuberculosis , gastroenterology , pathology , surgery , adenosine , pharmacokinetics
Tuberculous meningitis is an infection of the meninges caused by Mycobacterium tuberculosis . It is one of the most common infectious diseases of the Central Nervous System (CNS) and a major health problem in developing countries like India. If there is delay in diagnosis and initiation of specific treatment, it causes significant morbidity and mortality. CSF-ADA 10 U/l is the standard cut off value that is used for differentiation between Tuberculous (TBM) and Non-Tuberculous Meningitis (non-TBM).