Open AccessImmunohistochemical Expression of Caspase 3 in Psoriasis
Author(s) -
Shaimaa M.M. Bebars,
Dalia Rifaat Al-Sharaky,
Mohamed A Gaber,
Dina Ragab Afify
Publication year - 2017
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2017/25609.10145
Subject(s) - psoriasis , medicine , pathogenesis , immunohistochemistry , apoptosis , dermis , skin biopsy , outpatient clinic , dermatology , biopsy , pathology , immunology , biology , biochemistry
Psoriasis is a persistent chronic immune-mediated, relapsing, inflammatory and hyper proliferative skin disorder with genetic predisposition. Psoriasis can be considered as a T-cell mediated disease, with a complex role for a variety of cytokine interaction between keratinocytes and T-lymphocytes. Caspase-3 is an enzyme that plays a key role in apoptosis; it is a member of the family of cysteinyle aspartate specific proteases.