Open AccessComparative Evaluation of Ropivacaine and Fentanyl Versus Ropivacaine and Fentanyl with Clonidine for Postoperative Epidural Analgesia in Total Knee Replacement Surgery
Author(s) -
Shivali Panwar,
Preeti S Govind,
Parag Jyoti Duarah,
Hari Kishan Mahajan,
Smita Anil Korde
Publication year - 2017
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2017/25401.10615
Subject(s) - ropivacaine , fentanyl , medicine , clonidine , anesthesia , analgesic , sedation , nausea , vomiting , visual analogue scale , surgery
Clonidine an alpha 2 adrenoceptor agonist possesses analgesic properties and has been used as an adjuvant in epidural analgesia. The addition of clonidine to other analgesics may result in enhanced analgesia through additive mechanisms or synergistic mechanisms. The enhanced analgesia may lead to a decrease in the dosage of analgesic drugs along with reduction of side effects.