Open AccessPre-microRNA Gene Polymorphisms and Risk of Cervical Squamous Cell Carcinoma
Author(s) -
Shruti Srivastava,
Shalini Singh,
Nosheen Fatima,
Balraj Mittal,
Anand Srivastava
Publication year - 2017
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2017/25361.10543
Subject(s) - microrna , genotype , cervical cancer , single nucleotide polymorphism , allele , biology , genetic predisposition , gene , oncology , genetics , restriction fragment length polymorphism , bioinformatics , cancer , medicine
MicroRNAs (miRNAs) are short (~22 nucleotides) regulatory RNAs that can modulate gene expression and are aberrantly expressed in many diseases, including cancer. It has been suggested that, the presence of single nucleotide polymorphisms in precursor miRNAs (pre-miRNAs) can alter miRNA processing, expression and binding to target mRNA and represents another type of genetic variability, that can contribute to the susceptibility of human cancers.