Open AccessClear Cell Adenocarcinoma of Female Urethra
Author(s) -
Sharada Rane,
Ashwini Ghodke,
Sharvari D Vishwasrao
Publication year - 2017
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2017/25261.10127
Subject(s) - histogenesis , urethra , clear cell adenocarcinoma , urothelium , adenocarcinoma , genitourinary system , medicine , immunohistochemistry , pathology , carcinoma , urology , urinary bladder , anatomy , clear cell , cancer
Primary malignancies of female urethra are infrequent, constituting a fraction of less than 1% of genitourinary malignancies. Primary clear-cell adenocarcinoma of the urethra, is even rarer, that histomorphologically resembles clear-cell carcinoma of the female genital tract, occurs predominantly in women and is associated with a relatively poor prognosis. The histogenesis of this rare urethral neoplasm has not been completely determined. Various hypotheses concerning the origin have been postulated, including (1) diverticular origin (2) mullerian origin (3), glandular differentiation of urothelium or urothelial carcinoma. Here, we report a case of 67-year-old female with obstructive urinary symptoms and pain in abdomen, diagnosed with adenocarcinoma of urethra. Immunohistochemistry (IHC) workup of the tumour was done to find the origin of the tumour.