Open AccessEffect of Sodium Valproate and Docosahexaenoic Acid on Pain in Rats
Author(s) -
Sushil Kiran Kunder,
Laxminarayana Kurady Bairy,
Avinash Arivazhahan
Publication year - 2017
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2017/25036.9596
Subject(s) - analgesic , valproic acid , pharmacology , sodium , medicine , docosahexaenoic acid , intraperitoneal injection , anesthesia , tramadol , chemistry , epilepsy , fatty acid , polyunsaturated fatty acid , biochemistry , organic chemistry , psychiatry
Analgesics are commonly prescribed medications used to alleviate pain of various aetiologies without affecting the patient's consciousness. They interfere with the transmission of pain signals. A commonly used antiepileptic drug, sodium valproate has been used in various non-epileptic conditions like migraine prophylaxis and in the treatment of bipolar disorder because of the multiple mechanisms by which it acts. Docosahexanoic Acid (DHA), an omega 3 fatty acid, is known to possess analgesic activity. We planned a study to assess the effect of sodium valproate alone and in combination with DHA in rat models of pain.